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High magnification of synaptophysin immunoreactivity in the hippocampus of a 10-month-old APPSL/PS1ho KI mouse, showing the diminished synaptophysin signal from the core of an amyloid deposit (asterisk). Note the enlarged SIPBs (synaptophysin-immunoreactive presynaptic boutons) surrounding the plaque (black arrows). The scale bar represents 300 µm.
