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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: Cytometry A. 2013 Oct 17;83(12):1096–1104. doi: 10.1002/cyto.a.22401

Figure 5. Tacrolimus inhibition of NFAT1 nuclear translocation in vivo is time-dependent.

Figure 5

NFAT1 nuclear translocation, measured by Rd Value, in CD4+ T cells at tacrolimus trough (time zero) and over the first 6 hours post-tacrolimus administration for 3 stable renal transplant recipients is shown. Each graph represents a different patient, labeled A-C. A concentration dependent decline in NFAT1 translocation in the CD4+ T cell sub-population was observed between 1 to 4 hours in evaluated with serial timed specimen collections. The maximum NFAT1 inhibition corresponds with the peak levels of tacrolimus in whole blood (grey line, left axis) measured by immunoassay.