Table 1.

Cyclosporine and Tacrolimus Dose and AUC (weight and dose normalized) for Weeks 2 –12 and 28–104 (data reported as median or median [IQR]) compared to nonHIV transplant (tx)

CsA	wks 2–12			wks 28–104
	n*	Dose (mg/kg)	AUC (ng*hr/mL/mg/kg)	n*	Dose (mg/kg)	AUC (ng*hr/mL/mg/kg)
nonHIV tx†	55	4	7000–9000	55	2	4500–6000
+PI	34	0.36	5759 [3325–8045]	16	0.34	5603 [3867–6658]
+EFV	18	4.03	862 [744–1131]	4	1.74	1201 [992–1422]
+NVP	18	2.21	1945 [1585–3277]	21	1.47	1905 [1486–2557]
+PI +EFV	3	4.03	10290 [8887–13778]	N/A	N/A	N/A
+PI +NVP	10	0.50	6718 [3933–7941]	10	0.63	5007 [3281–9168]

TAC	wks 2–12			wks 28–104
	n*	Dose (mg/kg)	AUC (ng*hr/mL/mg/kg)	n*	Dose (mg/kg)	AUC (ng*hr/mL/mg/kg)
nonHIV tx†	44	0.10	2000–5000	44	0.15	2000–5000
+PI	8	0.007	24996 [18205–41601]	3	0.003	34653 [17208–42250]
+EFV	3	0.058	2170 [936–3261]	4	0.046	1911 [1423–3071]
+NVP	5	0.021	3644 [3115–5157]	6	0.029	4220 [2703–6229]

^*number of PK studies

^†from ref [18].