Table 2.

Cyclosporine PK Parameters in the presence of PIs and the NNRTIs efavirenz and nevirapine (data reported as median or median [IQR]) compared to nonHIV transplant patients

		CsA CL/F (mL/hr/kg)	Ratio to PI	CsA V/F (L/kg)	Ratio to PI	CsA CL/V (/hr)	Ratio to PI
nonHIV tx†		480	(2.7)*	5	(1.8)*	0.096	(1.5)*
Co-medication
PI	wks 2–12	174 [124–301]	1	2.87 [1.62–4.06]	1	0.0606	1
	wk 28, 52, 104	179 [150–266]	1	2.78 [2.00–4.11]	1	0.0644	1
EFV	wks 2–12	1159 [884–1344]	6.66	9.11 [5.34–10.74]	3.17	0.127	2.10
	wk 28, 52	835 [711–1029]	4.66	5.79 [3.40–10.41]	2.08	0.144	2.24
NVP	wks 2–12	514 [305–631]	2.95	5.07 [2.80–6.35]	1.77	0.101	1.67
	wk 28, 52, 104	525 [391–673]	2.93	4.89 [3.37–5.67]	1.76	0.107	1.67
PI +EFV	wks 2–12	97 [73–113]	0.56	1.30 [1.25–2.49]	0.45	0.075	1.23
	wk 28, 52	N/A		N/A		N/A
PI +NVP	wks 2–12	149 [126–254]	0.86	1.63 [1.56–2.09]	0.57	0.0914	1.51
	wk 28, 52, 104	201 [109–305]	1.12	2.14 [1.46–2.48]	0.77	0.0939	1.46

^†from ref [18]

^*average for both PI time periods

^$ratio to PI: data for each drug at each time interval divided into the average for the PI parameter for that interval