Table 3.

Tacrolimus PK Parameters in the presence of PIs and and the NNRTIs efavirenz and nevirapine (data reported as median or median [IQR]) compared to nonHIV transplant patients.

		TAC CL/F (mL/hr/kg)	Ratio to PI$	TAC V/F (L/kg)	Ratio to PI	TAC CL/V (/hr)	Ratio to PI
nonHIV tx†		350	(10.1)*	6	(6.2)*	0.058	(1.6)*
Co-medication
PI	wks 2–12	40 [24–56]	1	0.94 [0.64–1.29]	1	0.043	1
	wk 28, 52	29 [24–58]	1	0.99 [0.31–1.19]	1	0.029	1
EFV	wks 2–12	461 [307–1068]	11.5	6.26 [5.42–10.91]	6.66	0.074	1.72
	wk 28, 52, 104	526 [366–748]	18.1	7.70 [6.22–10.70]	7.78	0.068	2.33
NVP	wks 2–12	274 [194–321]	6.85	4.89 [2.74–6.16]	5.20	0.056	1.31
	wk 28, 52, 104	253 [161–370]	8.72	8.09 [3.46–15.14]	8.17	0.031	1.07

^†from ref [18]

^*average for both PI time periods

^$ratio to PI: data for each drug at each time interval divided into the average for the PI parameter for that interval