Table 3.

Haplotype analyses for rs17782313 and rs17700633 with obesity-related phenotypes

Haplotype	Frequency (%) EA/AA	male		female
		β (SE)	P	β (SE)	P
%BF
1(TG)	61.3/52.8	–	–	–	–
2(TA)	16.7/21.2	−3.6(2.0)	0.07	3.9(1.7)	0.02
3(CG)	9.5/16.9	−5.5(2.2)	0.01	2.3(2.0)	0.25
4(CA)	12.5/10.1	4.2(2.1)	0.05	4.7(2.0)	0.02
Overall P Value/Variance (%)		–	0.01/3.1	–	0.007/2.8
VAT(cm3)
1(TG)	61.3/52.8	–	–	–	–
2(TA)	16.7/21.2	−0.3(0.2)	0.16	0.4(0.2)	0.03
3(CG)	9.5/16.9	−0.1(0.2)	0.53	0.2(0.2)	0.49
4(CA)	12.5/10.1	0.2(0.2)	0.22	0.5(0.2)	0.04
Overall P Value/Variance (%)		–	0.28	–	0.01/5.5
SAAT(cm3)
1(TG)	61.3/52.8	–	–	–	–
2(TA)	16.7/21.2	−0.1(0.2)	0.58	0.6(0.2)	0.001
3(CG)	9.5/16.9	−0.1(0.3)	0.69	0.5(0.2)	0.03
4(CA)	12.5/10.1	0.1(0.3)	0.70	0.4(0.2)	0.04
Overall P Value/Variance (%)		–	0.91	–	0.003/5.7

%BF=% body fat; VAT=visceral adipose tissue, SAAT= subcutaneous abdominal adipose tissue, EA: European-American, AA: African-American.

P values: adjusted for age, ethnicity and cohort.