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. Author manuscript; available in PMC: 2015 Apr 24.
Published in final edited form as: Chem Biol. 2014 Mar 20;21(4):453–458. doi: 10.1016/j.chembiol.2014.02.011

Figure 2.

Figure 2

Comparison between HER3/bosutinib, Abl/bosutinib and CamKII/bosutinib complexes, (A), (B), and (C), respectively. Upper panels show cartoon representations highlighting the overall organization of the structurally aligned kinase domains. Helix αC is shown in blue and the activation loop of each kinase is shown in red. Carbon atoms of bosutinib are shown in magenta. Lower figures show a close up view of the interactions between bosutinib and the DFG motif of each kinase domain. Abl/bosutinib PDB ID: 3UE4. CamKII/bosutinib PDB ID: 3SOA.