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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Neurosci Lett. 2013 Aug 19;562:91–96. doi: 10.1016/j.neulet.2013.08.017

Fig. 1.

Fig. 1

Rats with sham surgery or SNL received duloxetine (30 mg/kg, i.p.) or morphine (10 mg/kg, i.p.). SNL surgery significantly lowered paw withdrawal thresholds of rats, and duloxetine (A) or morphine (B) attenuated tactile hypersensitivity, as shown by the significant (p < 0.05) increases in paw withdrawal thresholds. Vehicle injection did not alter CSF NE levels of sham-operated (C) or SNL (D) rats 30 or 60 min after injection. Duloxetine (30 mg/kg, i.p.) produced a significant (p < 0.05) elevation of CSF NE at both time points. The increases in NE were similar for sham-operated (C) and SNL (D) rats. Morphine produced a significant (p < 0.05) reduction of CSF NE levels in both sham-operated (C) or SNL (D) rats 30 or 60 min after injection. *p < 0.05; N = 7–12 rats per group.