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. 2014 May 12;9(5):e97229. doi: 10.1371/journal.pone.0097229

Figure 1. Polyclonal antibodies from naturally infected donors have a wide range of non-neutralizing anti-viral activities.

Figure 1

Antibodies purified from the plasma of 15 different elite controllers (labeled EC-1 to EC15) were tested for their ability to bind to gp120 by ELISA, shown as the inverse of EC50 (A), to mediate ADCVI, measured as a percent of inhibition of viral replication (B) and to neutralize HIV virus (JRCSF), measured as an inverse of EC50 (C). The correlation plots show the relationship between gp120-specific antibody titers from elite controllers and ADCVI activity (D), or virus neutralization (E) as well as the association between the neutralization and ADCVI activity of antibodies (F). The elite controller from which the purified antibodies had the greatest innate immune recruiting properties in the absence of neutralization, EC10, was selected for passive transfer into macaques and is highlighted in gray. A minimum of 2 separate experiments was assessed to select the EC antibodies that had the best activity.