. 2014 May 12;9(5):e97133. doi: 10.1371/journal.pone.0097133

Table 1. Quantitative analysis of gene expression ^a at 24 hpf.

Genotype Gene^b	adar2MOc (n = 3)^c	adar2MOsp (n = 4)	adar2MOt (n = 7)	adar2MOt-p53^AUG (n = 3)	gria2αQRMO (n = 3)
adar2	0.98±0.1	0.42±0.24^*	0.62±0.1^*	2.83±0.6^**	0.79±0.14
gria1α	0.9±0.15	0.52±0.41	0.81±0.4	1.15±0.2	0.81± 0.14
gria2α	0.86±0.09	0.45±0.37	0.66±0.58	1.53±1.07	0.84±0.14
cycg1	1.38±0.14	6.04±4.52	9.18±2.17^*	4.79±1.02^*	3.2±0.63^*
mdm2	1.17±0.14	3.09±1.9	3.66±0.5^*	2.64±2.0	12.27±2.46^*
Δ113p53	1.34±0.39	22.84 ± 18.32	20.1±7.8^*	14.76±28.66	156.78±23.51^*
3′-p53	1.2±0.16	4.07±2.77	5.5±0.39^*	not determined	not determined
5′-p53	1.16±0.16	1.21±0.7	1.23±0.36	1.2±0.89	1.02±0.38
neuroD	0.96±0.06	0.39±0.25^*	0.63±0.21^*	0.92±0.1^**	0.81±0.15
neurog1	0.92±0.06	0.57±0.31	0.81±0.11	1.04±0.11^**	0.75 ± 0.14
sox9a	1.15±0.22	1.19±0.26	1.15±0.16	not determined	0.89±0.06
sox9b	1.08±0.1	0.64±0.01^*	0.41±0.17^*	not determined	0.55±0.05^*

: a relative gene expression level was determined and then normalized to the expression level of β-actin (actb1). The values (mean ± standard deviation) are the relative gene expression levels of morphants compared to those of the wild type (un-injected) of the same batch.

* indicates significant difference (p<0.05) between hypo-Q/R-editing morphants and adar2 control morphant (adar2MOc)

** indicates significant difference between adar2MOt-p53^AUG and adar2MOt.

: Accession numbers are listed in Table S1. neuroD and neurog1 (neurogenin 1) are proneuron genes; ccng1(cyclin G1), mdm2 and Δ113p53 (a short isoform of p53 transcribed from an internal promoter) are p53-responsible genes. 3′-p53 and 5′-p53 respectively represent transcripts encoding all the isoforms of p53 and long isoform of p53. sox9a and sox9b are expressed in the neural crest cells and other cell types.

: n, number of independent injection

Table 1. Quantitative analysis of gene expression a at 24 hpf.

Table 1. Quantitative analysis of gene expression ^a at 24 hpf.