Table 3. Anatomical regions showing areas where statistical significant BOLD fMRI response to heat-pain stimuli were greater than baseline temperature for Healthy Volunteers and myeloma patients with CIPN.

Healthy volunteers: Pain>Baseline
Region	BA	Talairach co-ordinates	Peak t	p (FWE-corr)	Voxels*
R anterior cingulate	32	4 24 23	7.47	<0.001	1643
L superior temporal gyrus	38	−50 13 −8	7.19	<0.001	1491
L posterior cerebellar lobe	-	−30 −67 −20	6.56	0.002	2917
R inferior frontal gyrus	47	44 20 −9	6.52	0.002	1151
R supramarginal gyrus	40	64 −41 34	6.36	0.004	687
L superior temporal gyrus	42	−60 −30 18	6.13	0.007	709
L superior frontal gyrus	10	−32 48 20	5.80	0.018	469
R middle frontal gyrus	46	42 44 24	5.73	0.02	390
R superior frontal gyrus	8	6 39 48	5.68	0.025	216
L postcentral gyrus	7	−20 −41 68	5.66	0.026	212

*Voxels  =  number of voxels exceeding threshold p<0.001, uncorrected