Table 3. Anatomical regions showing areas where statistical significant BOLD fMRI response to heat-pain stimuli were greater than baseline temperature for Healthy Volunteers and myeloma patients with CIPN.
Healthy volunteers: Pain>Baseline | |||||
Region | BA | Talairach co-ordinates | Peak t | p (FWE-corr) | Voxels* |
R anterior cingulate | 32 | 4 24 23 | 7.47 | <0.001 | 1643 |
L superior temporal gyrus | 38 | −50 13 −8 | 7.19 | <0.001 | 1491 |
L posterior cerebellar lobe | - | −30 −67 −20 | 6.56 | 0.002 | 2917 |
R inferior frontal gyrus | 47 | 44 20 −9 | 6.52 | 0.002 | 1151 |
R supramarginal gyrus | 40 | 64 −41 34 | 6.36 | 0.004 | 687 |
L superior temporal gyrus | 42 | −60 −30 18 | 6.13 | 0.007 | 709 |
L superior frontal gyrus | 10 | −32 48 20 | 5.80 | 0.018 | 469 |
R middle frontal gyrus | 46 | 42 44 24 | 5.73 | 0.02 | 390 |
R superior frontal gyrus | 8 | 6 39 48 | 5.68 | 0.025 | 216 |
L postcentral gyrus | 7 | −20 −41 68 | 5.66 | 0.026 | 212 |
*Voxels = number of voxels exceeding threshold p<0.001, uncorrected