Left panels: relaxant reactivity of mesenteric arteries to ACh. A: concentration-response curves for Sham groups, % of relaxation; B: concentration-response curves for CPB groups, % of relaxation; C: AUC values of the relaxant responses to ACh, au. Right panels: relaxant reactivity of coronary arteries to ACh. D: concentration-response curves for Sham groups, % of relaxation; E: concentration-response curves for CPB groups, % of relaxation; F: AUC values of the relaxant responses to ACh, au. Abbreviations: CBP, cardiopulmonary bypass; PE, phenylephrine; SE, serotonin. Data are mean±SEM. a- indicates P<0.05 vs Control-Vehicle, t-test. b- indicates P<0.05 vs Sham 2 days, t-test.