Table 1. Data on blood gas analysis and hematocrit in Sham and CPB groups.
Sham | Vehicle Before ECC | Vehicle 15 min ECC | Vehicle 45 min ECC | Vehicle After ECC | FTY720 Before ECC | FTY720 15 min ECC | FTY720 45 min ECC | FTY720 After ECC | SEW2871 Before ECC | SEW2871 15 min ECC | SEW2871 45 min ECC | SEW2871 After ECC |
pH | 7.43±0.05 | 7.45±0.05 | 7.46±0.07 | 7.41±0.06 | 7.4±0.02 | 7.4±0.03 | 7.4±0.03 | 7.36±0.03 | 7.4±0.02 | 7.4±0.02 | 7.37±0.03 | 7.35±0.01 |
pCO2 | 4.74±1.0 | 4.51±0.8 | 4.68±1.0 | 5.15±0.9 | 4.8±0.3 | 4.6±0.3 | 5.0±0.3 | 5.6±0.4 | 4.7±0.3 | 4.7±0.3 | 5.7±0.5 | 5.9±0.3 |
HCO3 | 17.4±4.7 | 16.6±3.9 | 17.7±4.2 | 16.9±4.6 | 22.1±0.3 | 22.3±0.5 | 23.8±0.5 | 23.8±0.5 | 21.5±0.8 | 21.5±0.7 | 23.9±0.7 | 23.9±0.5 |
BE | 22.9±1.5 | 23.3±1.6 | 24.7±1.6 | 24.4±2.2 | −1.8±0.4 | −0.84±0.5 | 0.05±0.3 | −1.4±0.4 | −2.1±0.6 | −1.9±0.5 | −0.7±0.7 | −1.2±0.4 |
Hctc | 0.41 ±0.02 | 0.41±0.03 | 0.42±0.03 | 0.43±0.03 | 0.41±0.02 | 0.41±0.01 | 0.36±0.03 | 0.32±0.02 | 0.36±0.01 | 0.41±0.02 | 0.32±0.01 | 0.32±0.01 |
Abbreviation: CPB, cardiopulmonary bypass; ECC, extracorporeal circulation; BE, Hctc; Before ECC, 15 min before the start of extracorporeal circulation; 15 min ECC, 15 min after the start of extracorporeal circulation; 45 min ECC, 15 min before the end of extracorporeal circulation; after ECC, 15 min after the end of extracorporeal circulation.
a-P<0.05 vs Sham untreated, t-test; b-P<0.05 vs Sham FTY720, t-test; c-P<0.05 vs Sham SEW2871, t-test.