Figure 9. Human cells engrafted in the mouse liver.

Human B2M⁺ cells (green) are seen growing as colonies in the parenchyma (top row). These cells are small elongated cells located around mouse hepatocytes and lining sinusoids, indicative of LSECs. Human CD45⁺ leukocytes (green) are found dispersed throughout the liver parenchyma as well as in some blood vessels (middle row). Note the presence of small clusters of leukocytes. LSECs stain brightly for CD34 (green) and are shown to be in close contact with the human CD45⁺ leukocytes (bottom row). Mouse cells are stained in the top two rows using anti-H-2K^d (red) and blue staining represents nuclei stained with DAPI. The fold-magnification used is indicated for each photograph.