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. Author manuscript; available in PMC: 2014 May 12.
Published in final edited form as: Immunity. 2010 Aug 27;33(2):216–228. doi: 10.1016/j.immuni.2010.08.003

Figure 5. DCs Lacking α-Gal-A Amplify Antimicrobial Responses by iNKT Cells.

Figure 5

DCs from WT, Myd88−/−, Gla−/−, and Gla−/− Cd1d1−/− mice were incubated for 16 hr with L. monocytogenes, LPS (1 μg/ml), CpG ODN (2 μg/ml), or were left untreated, prior to coculture with liver iNKT cells. After 72 hr, IFN-γ release into the culture supernatants was quantified by ELISA. Results are representative of at least three independent experiments with similar results. Error bars depicted in column graphs represent mean values ± SEM of triplicate cultures. *p < 0.05; **p < 0.01; ***p < 0.001 as analyzed by Student’s t test. NS, not significant.