. Author manuscript; available in PMC: 2015 Feb 1.

Published in final edited form as: Mol Genet Metab. 2013 Dec 11;111(2):101–106. doi: 10.1016/j.ymgme.2013.11.013

Table 3.

Annual change in body composition in hGH vs. no hGH treatment groups.

	hGH treatment – no hGH treatment	P value
Hurler syndrome (n=15)^†
LBM, kg/year	0.4 (0.2)	.034
Body fat, %/year^*	0.3 (0.7)	.665
Total body BMD, gm/cm³/year	.005 (.005)	.371
Lumbar spine BMD, gm/cm³/year	.005 (.014)	.749
Hunter syndrome (n=10)^††
LBM, kg/year	0.8 (0.5)	.155
Body fat, %/year^*	-1.9 (1.9)	.333
Total body BMD, gm/cm²/year	.019 (.009)	.071
Lumbar spine BMD, gm/cm²/year	.036 (.014)	.033

Difference between groups estimate (SE). hGH=human growth hormone; LBM=lean body mass; BMD=bone mineral density.

^†

Hurler outcomes adjusted for age, height, Tanner stage and sex.

^††

Hunter outcomes adjusted for age, height, and Tanner stage.

Body fat not adjusted for height.