Table 1. Differentially expressed proteins between male and female in either anterior cruciate ligament (ACL), or patellar tendon (PT) or both.
| ACL | PT | |||||||||
| Primary Protein Name | Protein Description | GENE | Peptide Count | Fold Change M/F | ANOVA p-value | Cohen's d | Peptide Count | Fold Change M/F | ANOVA p-value | Cohen's d |
| ACTH_HUMAN† | Actin, gamma-enteric smooth muscle | ACTG2 | 8 | −1.14 | 8.29E-01 | −0.27 | 9 | 1.76 | 1.80E-02 | 2.08 |
| ADH1B_HUMAN* | Alcohol dehydrogenase 1B | ADH1B | 2 | −4.98 | 2.00E-03 | −3.54 | 1 | −8.64 | 9.38E-15 | −9.59 |
| ALBU_HUMAN | Serum albumin | ALB | 40 | 2.24 | 1.41E-08 | 5.40 | 62 | 2.48 | 6.25E-14 | 8.10 |
| ANXA2_HUMAN | Annexin A2 | ANXA2 | 3 | 1.38 | 8.25E-01 | 0.74 | 6 | 1.56 | 1.80E-02 | 2.13 |
| CO1A1_HUMAN | Collagen alpha-1(I) chain | COL1A1 | 210 | −1.20 | 8.83E-04 | −4.29 | 520 | −1.20 | 2.10E-02 | −2.12 |
| CO1A2_HUMAN | Collagen alpha-2(I) chain | COL1A2 | 186 | −1.23 | 7.00E-03 | −3.06 | 374 | −1.12 | 4.20E-02 | −1.76 |
| CO6A1_HUMAN | Collagen alpha-1(VI) chain | COL6A1 | 50 | −1.00 | 8.99E-01 | −0.02 | 61 | 1.41 | 4.50E-02 | 2.29 |
| CO9_HUMAN | Complement component C9 | C9 | 3 | −4.56 | 1.15E-09 | −3.94 | 2 | −2.10 | 2.44E-01 | −1.50 |
| LUM_HUMAN | Lumican | LUM | 13 | −1.02 | 8.27E-01 | −0.08 | 9 | 1.81 | 9.38E-15 | 10.36 |
| MIME_HUMAN | Mimecan | OGN | 15 | 1.30 | 8.30E-01 | 0.55 | 7 | 1.31 | 1.99E-06 | 5.15 |
| MMP3_HUMAN | Stromelysin-1 | MMP3 | 4 | −2.14 | 7.17E-04 | −2.27 | ||||
| MYOC_HUMAN | Myocilin | MYOC | 3 | 3.88 | 2.00E-03 | 2.57 | 4 | 1.20 | 8.53E-01 | 0.38 |
| PGS2_HUMAN | Decorin | DCN | 26 | −1.22 | 9.45E-09 | −6.42 | 25 | −1.02 | 7.51E-01 | −0.36 |
| TSP1_HUMAN | Thrombospondin-1 | THBS1 | 3 | −1.32 | 8.27E-01 | −0.83 | 5 | −2.04 | 1.80E-02 | −1.95 |
| TTHY_HUMAN | Transthyretin | TTR | 14 | 21.72 | 6.72E-01 | 0.98 | 2 | 1.83 | 2.30E-02 | 1.87 |
| VIME_HUMAN | Vimentin | VIM | 6 | 1.66 | 3.24E-01 | 1.18 | 3 | 2.01 | 1.90E-02 | 1.99 |
The table was curated from Tables S3 and S4 using >1 peptide count for either ACL or PT, an ANOVA p-value <0.05 after Hochberg FDR correction for ACL or PT, and Cohen's d for the individual analyte of >0.8. If these criteria were not met for both ACL and PT, the data for the other tissue (italics) were included for completeness.
*A single peptide was identified in PT which was homologous to ADH1B, ADH1C, and ADH1G. This single peptide was annotated somewhat arbitrarily to ADH1G in the PT dataset (Table S2) because of ProteinProphet homology rules and was also identified and quantified in the ACL dataset (Table S1). The statistical data has been inserted here for ADH1B because of its consistency between ACL and PT.
all peptides identified as ACTS in PT also map to ACTH in ACL, but the converse is not true for all peptides mapped as ACTH in ACL. Therefore both identifications were represented as ACTH.