Figure 2. Effect of transradial vs. transfemoral approach on death.

2A. Odds ratio of death with transradial vs. transfemoral approach. The squares and the horizontal lines indicate the OR and the 95% CIs for each trial included; the size of each square is proportional to the statistical weight of a trial in the meta-analysis; diamond indicates the effect estimate derived from meta-analysis, with the centre indicating the point estimate and the left and the right ends the 95% CI. M-H, Mantel-Hænzel model; D+L, DerSimonian and Laird model. 2B. Trial sequential analysis for death. Heterogeneity adjusted information size of 26,836 participants calculated on basis of death of 2.53% in the transfemoral group, relative risk reduction 20%, α = 5%, β = 20%, I² = 0%. Solid green cumulative Z-curve did not cross red dashed trial sequential monitoring boundaries for benefit or harm. Horizontal dotted green lines illustrate traditional level of statistical significance (p = 0.05).