Figure 5. Effect of transradial vs. transfemoral approach on vascular complications.

5A. Odds ratio of vascular complications with transradial vs. transfemoral approach. 5B. Trial sequential analysis for vascular complications. Heterogeneity adjusted information size of 1,769 participants calculated on basis of major bleeding of 5.12% in the transfemoral group, relative risk reduction 50%, α = 5%, β = 20%, I² = 0%. Solid green cumulative Z-curve crossed the red dashed monitoring boundaries, demonstrating sufficient evidence reached for 35% reduction in the risk of major bleeding with transradial approach. Horizontal dotted green lines illustrate traditional level of statistical significance (p = 0.05).