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. 2014 May 12;9(5):e97425. doi: 10.1371/journal.pone.0097425

Figure 7. Hitchhiking of DEFT/DEFTP during the birth-and-death evolution of the primate DEFA/DEFT multigene family.

Figure 7

A: Comparative synteny map of the DEFA/DEFT gene loci in humans, chimpanzees, orangutans, macaques and marmosets. The boxes highlight the two genes that are linked and duplicate together, including a driver from the DEFA1 cluster and a hitchhiker from the DEFT/DEFA10 cluster. Arrowheads indicate transcriptional orientation. Pseudogenes are in white, and functional genes are in black. The dashed-line box includes the pseudogene DEFTP containing the nonsense mutation at site 17. B: The NJ tree based on the introns of the boxed DEFT/DEFTP from humans (hspi), chimpanzees (ptro), orangutans (pabe) and macaques (mmul). The nonsense mutations (*) at codon site 17 of the pseudogenes hspi_DEFT1P, hspi_DEFT2P ptro_DEFT1P, ptro_DEFT2P and pabe_DEFT4P are underlined with dashed lines, suggesting that these DEFTP pseudogenes are derived from a common ancestor.