Table 3. Logistic regression analyses of associations between p21, p53, TP53BP1 and p73 polymorphisms and risk of ESCC.
| Genotype | Cases (n = 629) | Controls (n = 686) | Crude OR (95%CI) | p | Adjusted OR a (95%CI) | p | ||
| n % | n % | |||||||
| p21 rs2395655 G>A | ||||||||
| GG | 148 | 24.7 | 184 | 28.3 | 1.00 | 1.00 | ||
| GA | 327 | 54.5 | 318 | 48.8 | 1.28 (0.98–1.67) | 0.070 | 1.23 (0.94–1.62) | 0.128 |
| AA | 125 | 20.8 | 149 | 22.9 | 1.04 (0.76–1.44) | 0.798 | 1.00 (0.72–1.39) | 0.982 |
| GA+AA | 452 | 75.3 | 467 | 71.7 | 1.20 (0.94–1.55) | 0.150 | 1.16 (0.90–1.50) | 0.256 |
| GG+GA | 475 | 79.2 | 502 | 77.1 | 1.00 | 1.00 | ||
| AA | 125 | 20.8 | 149 | 22.9 | 0.89 (0.68–1.16) | 0.381 | 0.87 (0.66–1.15) | 0.332 |
| p21 rs1059234 C>T | ||||||||
| CC | 172 | 28.7 | 170 | 26.1 | 1.00 | 1.00 | ||
| CT | 321 | 53.5 | 340 | 52.2 | 0.93 (0.72–1.21) | 0.604 | 0.88 (0.67–1.15) | 0.334 |
| TT | 107 | 17.8 | 141 | 21.7 | 0.75 (0.54–1.04) | 0.086 | 0.72 (0.51–1.00) | 0.050 |
| CT+TT | 428 | 71.3 | 481 | 73.9 | 0.88 (0.69–1.13) | 0.311 | 0.83 (0.64–1.07) | 0.149 |
| CC+CT | 493 | 82.2 | 510 | 78.3 | 1.00 | 1.00 | ||
| TT | 107 | 17.8 | 141 | 21.7 | 0.79 (0.59–1.04) | 0.090 | 0.78 (0.59–1.04) | 0.089 |
| p21 rs3176352 G>C | ||||||||
| GG | 191 | 31.8 | 239 | 35.5 | 1.00 | 1.00 | ||
| GC | 258 | 43.0 | 316 | 47.0 | 1.02 (0.79–1.31) | 0.868 | 0.98 (0.76–1.27) | 0.866 |
| CC | 151 | 25.2 | 118 | 17.5 | 1.60 (1.18–2.18) | 0.0026 | 1.61 (1.18–2.20) | 0.0030 |
| GC+CC | 409 | 68.2 | 434 | 64.5 | 1.18 (0.93–1.49) | 0.166 | 1.15 (0.91–1.46) | 0.255 |
| GG+GC | 449 | 74.8 | 555 | 82.5 | 1.00 | 1.00 | ||
| CC | 151 | 25.2 | 118 | 17.5 | 1.58 (1.21–2.07) | 0.0009 | 1.63 (1.23–2.15) | 0.0006 |
| p21 rs1801270 C>A | ||||||||
| CC | 179 | 29.1 | 182 | 26.7 | 1.00 | 1.00 | ||
| CA | 322 | 52.3 | 346 | 50.8 | 0.95 (0.73–1.22) | 0.672 | 0.89 (0.68–1.15) | 0.373 |
| AA | 115 | 18.7 | 153 | 22.5 | 0.76 (0.56–1.05) | 0.097 | 0.72 (0.52–0.99) | 0.044 |
| CA+AA | 437 | 70.9 | 499 | 73.3 | 0.89 (0.70–1.14) | 0.349 | 0.84 (0.65–1.07) | 0.154 |
| CC+CA | 501 | 81.3 | 528 | 77.5 | 1.00 | 1.00 | ||
| AA | 115 | 18.7 | 153 | 22.5 | 0.79 (0.60–1.04) | 0.092 | 0.77 (0.59–1.02) | 0.070 |
| p21 rs762623 G>A | ||||||||
| GG | 480 | 77.9 | 537 | 78.9 | 1.00 | 1.00 | ||
| GA | 129 | 20.9 | 136 | 20.0 | 1.06 (0.81–1.39) | 0.667 | 1.06 (0.81–1.40) | 0.675 |
| AA | 7 | 1.1 | 8 | 1.2 | 0.98 (0.35–2.72) | 0.967 | 0.95 (0.33–2.70) | 0.923 |
| GA+AA | 136 | 22.1 | 144 | 21.1 | 1.06 (0.81–1.38) | 0.683 | 1.06 (0.81–1.38) | 0.700 |
| GG+GA | 609 | 98.9 | 673 | 98.8 | 1.00 | 1.00 | ||
| AA | 7 | 1.1 | 8 | 1.2 | 0.97 (0.35–2.68) | 0.949 | 0.94 (0.33–2.67) | 0.905 |
| p53 rs1042522 G>C | ||||||||
| GG | 177 | 28.8 | 213 | 32.6 | 1.00 | 1.00 | ||
| GC | 321 | 52.3 | 310 | 47.5 | 1.25 (0.97–1.61) | 0.089 | 1.19 (0.92–1.54) | 0.186 |
| CC | 116 | 18.9 | 130 | 19.9 | 1.07 (0.78–1.48) | 0.663 | 1.04 (0.75–1.44) | 0.810 |
| GC+CC | 437 | 71.2 | 440 | 67.4 | 1.20 (0.94–1.52) | 0.144 | 1.15 (0.90–1.46) | 0.273 |
| GG+GC | 498 | 81.1 | 523 | 80.1 | 1.00 | 1.00 | ||
| CC | 116 | 18.9 | 130 | 19.9 | 0.94 (0.71–1.24) | 0.648 | 0.93 (0.70–1.24) | 0.639 |
| TP53BP1 rs560191 G>C | ||||||||
| GG | 213 | 34.6 | 216 | 33.1 | 1.00 | 1.00 | ||
| GC | 291 | 47.3 | 290 | 44.4 | 1.02 (0.79–1.31) | 0.891 | 1.01 (0.78–1.30) | 0.959 |
| CC | 111 | 18.0 | 147 | 22.5 | 0.77 (0.56–1.05) | 0.092 | 0.76 (0.56–1.05) | 0.093 |
| GC+CC | 402 | 65.4 | 437 | 66.9 | 0.93 (0.74–1.18) | 0.558 | 0.92 (0.73–1.17) | 0.515 |
| GG+GC | 504 | 82.0 | 506 | 77.5 | 1.00 | 1.00 | ||
| CC | 111 | 18.0 | 147 | 22.5 | 0.76 (0.58–1.00) | 0.049 | 0.76 (0.57–1.01) | 0.055 |
| p73 rs1801173 C>T | ||||||||
| CC | 311 | 51.8 | 401 | 59.6 | 1.00 | 1.00 | ||
| CT | 251 | 41.8 | 235 | 34.9 | 1.38 (1.09–1.74) | 0.007 | 1.39 (1.10–1.76) | 0.006 |
| TT | 38 | 6.3 | 37 | 5.5 | 1.32 (0.82–2.13) | 0.248 | 1.27 (0.78–2.07) | 0.337 |
| CT+TT | 289 | 48.2 | 272 | 40.4 | 1.37 (1.10–1.71) | 0.006 | 1.37 (1.10–1.72) | 0.006 |
| CC+CT | 562 | 93.7 | 636 | 94.5 | 1.00 | 1.00 | ||
| TT | 38 | 6.3 | 37 | 5.5 | 1.16 (0.73–1.85) | 0.527 | 1.11 (0.69–1.79) | 0.667 |
| p21 rs3176352 G>C and p73 rs1801173 C>T combinations | ||||||||
| No risk variant genotypeb | 226 | 37.7 | 323 | 48.0 | 1.00 | 1.00 | ||
| Either one risk variant genotype | 308 | 51.3 | 310 | 46.1 | 1.42 (1.13–1.79) | 0.0030 | 1.42 (1.12–1.80) | 0.0035 |
| Both risk variant genotypes | 66 | 11.0 | 40 | 5.9 | 2.36 (1.54–3.62) | <0.0001 | 2.47 (1.60–3.82) | <0.0001 |
a
Adjusted for age, sex, smoking status and alcohol consumption;
b
Risk variant genotype means p21 rs3176352 CC or p73 rs1801173 CT/TT; p21 rs3176352 C vs. G OR = 1.26, 95% CI = 1.08–1.47, p = 0.0041; p73 rs1801173 T vs. C OR = 1.26, 95% CI = 1.05–1.50, p = 0.0126. Bonferroni correction (number of mutiple test = 32) was performed to correct the p value (p correct); for p21 rs3176352 G>C, the p correct = 0.096 for CC vs. GG after adjusted for age et al., p correct = 0.0192 for CC vs. GG/GC. For p73 rs1801173 C>T, the p correct = 0.202 for CT vs. CC after adjusted for age et al., p correct = 0.195 for CT/TT vs. CC. For the rest 6 SNPs, p correct>0.05 in all comparison models; Bold values are statistically significant (p<0.05).