. Author manuscript; available in PMC: 2015 Jun 1.

Published in final edited form as: Addiction. 2014 Mar 17;109(6):965–976. doi: 10.1111/add.12512

Table 4.

Logistic regression analysis of genetic influence and gene x environment interaction on MIP compared to non-MIP

	Univariate analyses		Wald	df	P values	Adjusted ORs	95% CI		G x E interaction^b (P values)
	χ², df	P values	Wald	df	P values	Adjusted ORs	Lower	Upper	G x E interaction^b (P values)
DBH gene ^a	4.9, 1	0.03	4	1	0.04 ^*	0.7	0.5	0.98	-
Severity of MA dependence	42, 1	<0.001	22	1	<0.001^**	3.4	2.1	5.7	0.02 ^*
Antisocial personality	22, 1	<0.001	14	1	<0.001^**	2.2	1.5	3.4	0.45
Alcohol dependence	21, 1	<0.001	4	1	0.05	1.4	1.0	2.1	0.99
Nicotine dependence	19, 1	<0.001	4	1	0.06	1.4	1.0	2.1	0.51

MIP = methamphetamine-induced paranoia, MA = methamphetamine, DBH = dopamine β-hydroxylase 95% CI = 95% confidence interval, df = degree of freedom, G x E = gene by environment

TT/CT compared to CC genotype.

After controlling for other clinical variables in the Table.

p < 0.05

^**

p < 0.001