Table 3.

Most connected nodes in the metabolite network. The degree is the number of metabolites that co-occur in metabolic reactions; the betweeness quantifies the number of paths between any two pairs of metabolites in the network that this one mediates (a global property)

Complete metabolite network (as in Fig 1A)			Abbreviated metabolite network (as in Fig 1B)
Metabolite	Degree	Betweeness	Metabolite	Degree	Betweeness
Proton	506	0.391	Coenzyme A	106	0.237
Water	390	0.226	L-glutamate1−	71	0.232
ATP	268	0.099	Acetyl-CoA	66	0.065
Diphosphate4−	181	0.062	2-oxoglutarate2−	48	0.078
Phosphate3−	178	0.041	Hydrogen peroxide	45	0.070
ADP	173	0.026	Pyruvate	38	0.070
NADPH	166	0.021	Glycine	31	0.041
NADP+	166	0.021	S-adenosyl-L-methionine	28	0.063
NAD+	143	0.018	Acetate	26	0.021
Carbon dioxide	139	0.020	S-adenosyl-L-homocysteine	25	0.039
NADH	139	0.017	(6S)-5,6,7,8-tetrahydrofolic acid	25	0.031
AMP	128	0.029	L-glutamine	25	0.025
Coenzyme A	119	0.021	Succinate2−	24	0.029
Dioxygen	116	0.014	Acyl-carrier protein	23	0.013
Ammonium	92	0.011	L-cysteine	22	0.023