Table 3.

Comparison of blocking current between BROMOC and available experiments. Currents in pA.

ss-DNA	Entrance Orientation	BROMOC		Exp. 151	Exp. 2*
		PROXDIFF on	PROXDIFF off
	αHL
Open Pore		416.6 ± 9.1		116 ± 3	212 ± 5
PolyA40	3′	4.1 ± 2.7	4.6 ± 3.4	18.6 ± 0.6	26.9
	5′	6.1 ± 2.4	6.0 ± 2.2	22.0 ± 0.6	33.1
PolyC40	3′	16.3 ± 11.2	14.3 ± 9.6	21.7 ± 0.6	30.3
	5′	18.4 ± 5.5	20.8 ± 6.2	20.3 ± 0.6	33.5
PolyT40	3′	11.2 ± 5.0	13.5 ± 4.3	19.2 ± 0.6	28.5
	5′	13.9 ± 3.2	13.1 ± 3.9	18.5 ± 0.6
	αHL-NYN
Open Pore		474.7 ± 6.4		-	216.3
PolyA40	3′	18.6 ± 6.4	-	-	29.2
	5′	20.3 ± 8.9	-	-	33.5
PolyC40	3′	31.5 ± 8.6	-	-	37.2
	5′	34.9 ± 9.0	-	-	37.7
PolyT40	3′	29.9 ± 5.4	-	-	-
	5′	28.6 ± 8.6	-	-	-

PROXDIFF: Ion Diffusion in proximity of DNA

^*Communicated by Electronic Bioscience (EBS).

Standard Deviation obtained from 25 independent BROMOC simulations.

Conditions:

αHL/BROMOC: C = 1 M KCl, V_mp = 250mV.

αHL/Exp 1: C = 1M of KCl, V_mp = 120 mV.

αHL-NYN/Exp 2 conditions: C = 3M of NaCl, V = 120 mV.