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. 2014 May 1;28(9):926–928. doi: 10.1101/gad.242420.114

Figure 1.

Figure 1.

SRF directs the nuclear response to two signaling pathways via TCFs or MRTFs. (A) Serum activates Rho signaling (which changes actin dynamics) and Ras/MAPK kinase cascade (which phosphorylates TCFs). G-actin binds MRTF directly and modulates its nucleo–cytoplasmic trafficking (Mouilleron et al. 2011). (B) In response to Rho-actin signaling, SRF binding to DNA is stimulated, which involves nucleosome displacement. MRTF’s DNA binding is interdependent with SRF DNA binding (Zaromytidou et al. 2006). In response to Ras/MAPK signaling, prebound SRF functions with TCF, which binds to DNA independently and binds SRF via a dedicated B-box (Mo et al. 2001).