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. 2014 May 1;28(9):959–970. doi: 10.1101/gad.236729.113

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© 2014 Chen and Gartenberg; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 7. — A model for coordinated transcription and export of pre-tRNAs from the nucleus. Increased transcription in M phase by RNA polymerase III is accompanied by repositioning of tDNAs at NPCs in a manner that depends on select Nups and the Los1 exportin. The model demands that nascent tRNAs mature at or near NPCs or that the transcripts synthesized at NPCs return to the nucleoplasm before export. Transcription outside of M phase when tDNAs are not enriched at NPCs requires that pre-tRNA transit through the nucleoplasm before export. Pre-tRNAs that leave the nucleus are spliced on the cytoplasmic surface of mitochondria.