Table 1.
OX1 aa | Corresponding aa in OX2 | Location | SNP (or other access code) | Numbering/peyron | Numbering/olafsdottir | Findings | References |
---|---|---|---|---|---|---|---|
167 Gly/Ser | Ile | TM4 | rs144603792 | 652 G/A | Not linked with narcolepsy | Olafsdottir et al., 2001 | |
265 Leu/Met | a | IC3 | 793 C/A | Not linked with narcolepsy | Peyron et al., 2000 | ||
279 Arg/Gln | a | IC3 | rs7516785 | 989 G/A | Not linked with narcolepsy | Olafsdottir et al., 2001 | |
280 Gly/Ala | a | IC3 | NP_001516 (C), AF041243 (G) | ||||
281 Arg/His | a | IC3 | rs41439244 | 842 G/A | 995 G/A | Not linked with narcolepsy | Peyron et al., 2000; Olafsdottir et al., 2001 |
408 Ile/Val | a | C-terminus | rs2271933 | 1222 G/A | 1375 G/A | Not linked with narcolepsy | Peyron et al., 2000; Olafsdottir et al., 2001 |
A allele associated with 1.4-fold risk of migraine | Rainero et al., 2011b | ||||||
1.6-fold increased risk of major mood disorders | Rainero et al., 2011a | ||||||
Association with polydipsia–hyponatremia in schizophrenia possible | Meerabux et al., 2005; Fukunaka et al., 2007 | ||||||
No allele associations in panic disorder | Annerbrink et al., 2011 | ||||||
OX2 aa | Corresponding aa in OX1 | Location | SNP | Numbering/peyron | Numbering/olafsdottir | Findings | References |
10 Pro/Ser | Pro | N-terminus | rs41271310 | 28 C/T | 352 C/T | Not linked with narcolepsy | Peyron et al., 2000; Olafsdottir et al., 2001; Thompson et al., 2004 |
11 Pro/Thr | a | N-terminus | rs41271312 | 31 C/A | 355 C/A | Not linked with narcolepsy | Peyron et al., 2000; Olafsdottir et al., 2001 |
Tourette syndrome/ADHD/sleep disorder 1.6 and 2.7-fold shifts in EC50 for orexin-A and -B | Thompson et al., 2004 | ||||||
193 Cys/Ser | a | TM4 | 577 T/A | Not linked with narcolepsy | Peyron et al., 2000 | ||
293 Ile/Val | a | IC3 | 1201 G/A | Not linked with narcolepsy | Olafsdottir et al., 2001 | ||
308 Ile/Val | Val | TM6 | rs265334 | 922 G/A | 1246 G/A | Not linked with narcolepsy | Peyron et al., 2000; Olafsdottir et al., 2001 |
Ile variant associated with panic disorder in female patients | Annerbrink et al., 2011 | ||||||
Migraine not associated. Association with CH found in some but not in all studies | Baumber et al., 2006; Schürks et al., 2006; Rainero et al., 2008 | ||||||
Does not affect migraine drug response | Schürks et al., 2007a | ||||||
401Thr/Ile | a | C-terminus | 1202 C/T | Not linked with narcolepsy | Peyron et al., 2000 |
aa, amino acid; IC, intracellular loop; SNP, single nucleotide polymorphism; TM, transmebrane helix.
The corresponding amino acids can be defined with certainty only for TM regions.