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. Author manuscript; available in PMC: 2014 May 13.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 May 16;49(9):4018–4025. doi: 10.1167/iovs.08-1914

Figure 3.

Figure 3

Photomicrographs showing that neutrophil depletion correlated with increased HSV-1 infection of the parenchyma of the anterior segment of the inoculated eye at day 5 pi. (A–D) In Gr-1–treated mice, HSV-1–infected cells were observed at day 5 pi in the ciliary body, in RPE cells and in some peripheral retinal cells; a few Gr-1+ neutrophils were also seen. (E–H) Diffuse HSV-1 infection of the ciliary body and sclera with massive infiltration of Gr-1+ neutrophils was observed in the injected eyes of control antibody–treated mice. In control mice, most of the Gr-1+ cells were also HSV-1+ (compare D with H). (A, E) HSV-1 staining; (B, F) Gr-1 staining; (C, G) DAPI; (D, H) merged images. S, sclera; J, junction of ciliary body and pars plana.