TABLE 1. Sample Demographics, GDS, Anxiety, PSS Scores, and Hippocampal Measurements.
| Total sample, N = 36 |
GDS (0–1), N = 11 |
GDS (2–4), N= 17 |
GDS (≥5), N= 8 |
|
|---|---|---|---|---|
| Women (%) | 47.2 | 63.6 | 47.1 | 25.0 |
| White (%) | 72.2 | 63.6 | 76.5 | 75 |
| Age, mean (SD), yr | 81.24 (5.43) | 80.00 (3.99) | 83.00 (4.615) | 79.21 (7.86) |
| Education, mean (SD), yr | 13.13 (3.07) | 12.63 (2.29) | 13.88 (3.72) | 12.25 (2.31) |
| BIMC total errors, median (range) | 2(0-6) | 2 (0-4) | 2 (0-6) | 1.5 (0-5) |
| BMI (SD) | 25.94 (4.87) | 27.11 (5.65) | 25.26 (2.73) | 25.76 (7.27) |
| FCSRT-IR free recall score, mean (SD) | 30.69 (6.71) | 30.64 (9.76) | 31.35 (5.57) | 29.38 (3.88) |
| FCSRT-IR total recall score, mean (SD) | 47.78 (1.33) | 47.27 (2.41) | 48.00 (0.00) | 48.00 (0.00) |
| Verbal IQ (SD) | 105.31 (17.03) | 98.45 (9.29) | 108.06 (21.67) | 109.43 (10.9) |
| SF-36 Anxiety score (SD) | 3.58 (1.91) | 2.27 (1.10) | 3.29 (1.57) | 6.00 (1.19) |
| PSS (SD)a | 18.25 (10.44) | 12.63 (10.82) | 20.07 (7.90) | 23.71 (11.19) |
| Hippocampal NAA/Cr, mean (SD) | 1.32 (0.23) | 1.34 (0.27) | 1.32 (0.23) | 1.29 (0.20) |
| Hippocampal volume (normalized), mean (SD) | 0.86 (0.14) | 0.95 (0.12) | 0.85 (0.14) | 0.76 (0.11) |
MRI volumetric data are given in cubic centimeters.
aPSS data available for n = 31.
BIMC = Blessed Information–Memory–Concentration test, total error score; BMI = Body Mass Index; FCSRT-IR = Buschke and Grober Free and Cued Selective Reminding Test–Immediate Recall; SF-36 = Short Form Health survey; PSS = Perceived Stress Scale; NAA/Cr = N-acetyl aspartate/creatine ratio.