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. 2014 May 12;205(3):377–393. doi: 10.1083/jcb.201309096

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© 2014 Vassilopoulos et al.

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Figure 10. — Sarcomeric disorganization and detachment between sarcolemma and myofibrils upon in vivo CHC depletion. Transmission electron microscopy of longitudinal (A–D, K–L) and transverse (E–J) muscle sections from mice injected with AAV-shCHC constructs at day 18 (A–G) and day 25 PI (H–L). In A–D, the sarcomeric apparatus is disorganized in focal regions adjoining the sarcolemma (within the dotted lines in A) and presents streaming and disassembly of the Z-line. C and D are insets of the respective boxed regions in B. In E–G, small detachments between the sarcolemma and the contractile apparatus are visible at day 18 PI. At day 25 PI, large detachments are seen in both transverse (H–J) and longitudinal orientation (K–L). I is an inset of the boxed region in H; J is an inset of the boxed region in I; L is an inset of the boxed region in K. Arrows in E, H, and L indicate detachments.