Table 1.
EphR signaling homologs in selected animals. Shown are components with evidence for a direct interaction with C. elegans VAB-1 (and homologs).
| Description | C. elegans | Drosophila | H. sapiens | Conserved EphR interaction? |
|---|---|---|---|---|
| Ligand, ephrin class | EFN-1 through EFN-41 | Ephrin | EphrinA1 through EphrinA5, EphrinB1 through EphrinB3 | Drosophila and mammals |
| Ligand, MSP class | MSPs (~28 genes) | None2 | None2 | Not applicable |
| Ligand, MSP/VAP class | VPR-1 | dVAP/VAP332 | VAPA and VAPB2 | Drosophila and mammals (Lua et al., 2011:3 PMID22069488; Tsuda et al., 2008: PMID18555774) |
| Ligand/co-receptor | WRK-1 | None3 | None3 | Not applicable |
| Eph Receptor | VAB-1 | Eph | EphA1 through EphA9, EphB1 through EphB5 | Not applicable |
| Adaptor | NCK-1 | Dock | NCK1 and NCK2 | Drosophila and mammals (Stein et al., 1998a:3 PMID9430661) |
| Adaptor | DAB-1 | Disabled | Disabled1 and Disabled2 | Not known |
| Effector, GTPase | RAN-1 | Ran | Ran | Not known |
| Effector, PTEN | DAF-18 | PTEN | PTEN | Not known |
1
EFN-4 binds to VAB-1 with lower affinity than other ephrin
2
There are additional proteins encoded by these genomes with an MSP domain (two in Drosophila and three in humans)
3
There are proteins encoded by these genomes with similar MAM domains