FIG 3.
Serum IgG and IgA responses to VN1203 and EG321 whole-virus antigen following vaccination with ca H5N1 viruses. Groups of 8 mice were inoculated i.n. with two doses of 300 MID50s of each virus 28 days apart or mock vaccinated. Blood was collected 28 days after the first dose and 28 days after the second dose. ELISA was performed using MDCK-grown whole viruses VN1203 (A) and EG321 (B) as antigens. Shown are the mean antibody titers from eight mice in each group ± SD (T lines). Statistically significant (P < 0.05) higher antibody titers detected after the second vaccination than after the first vaccination are indicated with an asterisk.