TABLE 2.

HRs (95% CIs) of cardiovascular disease mortality according to intakes of soy and soy components¹

	Quartile of intake
	1	2	3	4	P-trend2
Soy protein
Median intake, g/d	2.2	4.3	6.2	9.8
Cases/person-years, n/n	1224/219,813	1275/222,748	1204/223,036	1077/224,876
Multivariate model 1	1.00	1.02 (0.94, 1.11)	1.03 (0.95, 1.11)	1.00 (0.92, 1.08)	0.99
Multivariate model 2	1.00	1.00 (0.92, 1.08)	0.98 (0.90, 1.07)	0.99 (0.91, 1.07)	0.67
Multivariate model 3	1.00	1.02 (0.94, 1.11)	1.02 (0.93, 1.11)	1.06 (0.97, 1.17)	0.24
Soy isoflavones
Median intake, mg/d	6.2	13.1	19.2	32.0
Cases/person-years, n/n	1261/219,398	1314/221,609	1154/222,939	1051/226,528
Multivariate model 1	1.00	1.01 (0.93, 1.09)	0.96 (0.89, 1.05)	0.93 (0.86, 1.01)	0.06
Multivariate model 2	1.00	1.00 (0.92, 1.08)	0.95 (0.88, 1.04)	0.94 (0.86, 1.02)	0.08
Multivariate model 3	1.00	1.01 (0.93, 1.10)	0.98 (0.90, 1.07)	1.00 (0.91, 1.10)	0.83
Tofu equivalents
Median intake, g/d	42.8	61.2	99.9	197
Cases/person-years, n/n	1216/217,915	1284/221,868	1215/224,836	1065/225,855
Multivariate model 1	1.00	1.04 (0.96, 1.12)	1.04 (0.96, 1.12)	0.99 (0.91, 1.07)	0.77
Multivariate model 2	1.00	1.02 (0.94, 1.10)	1.02 (0.94, 1.11)	0.98 (0.90, 1.06)	0.62
Multivariate model 3	1.00	1.03 (0.95, 1.12)	1.06 (0.97, 1.15)	1.05 (0.95, 1.15)	0.27

¹Multivariate model 1 adjusted for age, sex, dialect, and year of interview; multivariate model 2 further adjusted for educational level, BMI, physical activity, smoking duration, cigarette smoking per day, alcohol use, baseline history of self-reported diabetes, hypertension, coronary heart disease, stroke, and total energy intake; multivariate model 3 further adjusted for dietary fiber, SFAs, MUFAs, ω-3 PUFAs, and ω-6 PUFAs.

²Linear trend was tested by treating the quartile as a continuous variable.