TABLE 3.
HRs (95% CIs) of CHD mortality and stroke mortality according to intakes of soy and soy components1
| Quartile of soy product intake |
|||||
| 1 | 2 | 3 | 4 | P-trend2 | |
| CHD mortality | |||||
| Soy protein | |||||
| Cases/person-years, n/n | 701/219,813 | 709/222,748 | 656/223,036 | 631/22,4876 | |
| Multivariate model 1 | 1.00 | 1.00 (0.90, 1.11) | 0.95 (0.85, 1.06) | 1.02 (0.92, 1.14) | 0.96 |
| Multivariate model 2 | 1.00 | 1.00 (0.90, 1.12) | 0.96 (0.86, 1.08) | 1.06 (0.93, 1.20) | 0.58 |
| Soy isoflavones | |||||
| Cases/person-years, n/n | 719/219,398 | 715/221,609 | 656/222,939 | 607/226,528 | |
| Multivariate model 1 | 1.00 | 0.98 (0.88, 1.09) | 0.98 (0.88, 1.10) | 0.96 (0.86, 1.08) | 0.57 |
| Multivariate model 2 | 1.00 | 0.98 (0.88, 1.09) | 0.99 (0.88, 1.11) | 0.99 (0.88, 1.12) | 0.97 |
| Tofu equivalents | |||||
| Cases/person-years, n/n | 686/217,915 | 717/221,868 | 679/224,836 | 615/225,855 | |
| Multivariate model 1 | 1.00 | 1.04 (0.93, 1.15) | 1.04 (0.94, 1.17) | 1.01 (0.90, 1.12) | 0.88 |
| Multivariate model 2 | 1.00 | 1.04 (0.93, 1.16) | 1.06 (0.94, 1.19) | 1.04 (0.92, 1.18) | 0.49 |
| Stroke mortality | |||||
| Soy protein | |||||
| Cases/person-years, n/n | 321/219,813 | 374/222,748 | 333/223,036 | 270/224,876 | |
| Multivariate model 1 | 1.00 | 1.05 (0.90, 1.23) | 0.99 (0.84, 1.16) | 0.91 (0.78, 1.08) | 0.20 |
| Multivariate model 2 | 1.00 | 1.09 (0.93, 1.27) | 1.05 (0.89, 1.24) | 1.02 (0.85, 1.23) | 0.96 |
| Soy isoflavones | |||||
| Cases/person-years, n/n | 335/219,398 | 386/221,609 | 307/222,939 | 270/226,528 | |
| Multivariate model 1 | 1.00 | 1.05 (0.90, 1.22) | 0.90 (0.76, 1.06) | 0.88 (0.75, 1.04) | 0.04 |
| Multivariate model 2 | 1.00 | 1.07 (0.92, 1.26) | 0.94 (0.80, 1.12) | 0.97 (0.81, 1.16) | 0.41 |
| Tofu equivalents | |||||
| Cases/person-years, n/n | 328/217,915 | 375/221,868 | 323/224,836 | 272/225,855 | |
| Multivariate model 1 | 1.00 | 1.04 (0.89, 1.21) | 0.95 (0.80, 1.11) | 0.90 (0.77, 1.06) | 0.12 |
| Multivariate model 2 | 1.00 | 1.07 (0.91, 1.25) | 1.00 (0.84, 1.18) | 1.00 (0.83, 1.20) | 0.78 |
1
Multivariate model 1 adjusted for age, sex, dialect, year of interview, educational level, BMI, physical activity, smoking duration, cigarette smoking per day, alcohol use, baseline history of self-reported diabetes, hypertension, CHD, stroke, and total energy intake; multivariate model 2 further adjusted for dietary fiber, SFAs, MUFAs, ω-3 PUFAs, and ω-6 PUFAs. CHD, coronary heart disease.
2
Linear trend was tested by treating the quartile as a continuous variable;