Table 1.
Patient, cancer, and treatment characteristics, by duration of filgrastim prophylaxis
| |
Study population, by days of filgrastim prophylaxis |
||
|---|---|---|---|
| 1-3 (n = 8,371) | 4-6 (n = 3,691) | > = 7 (n = 2,226) | |
|
Patient | |||
| Age (years), mean (SD) |
54.1 (12.5) |
57.4 (13.7) |
59.2 (12.9) |
| Men, % |
23.5 |
23.1 |
21.7 |
| Chronic comorbidities, % | |||
| Cardiovascular disease |
1.6 |
2.0 |
1.9 |
| Diabetes |
8.2 |
10.2 |
7.3 |
| Liver disease |
1.0 |
0.9 |
0.5 |
| Renal disease |
0.9 |
1.0 |
1.4 |
| History of other Conditions/Events Prior to Chemotherapy Course, % | |||
| Anemia |
15.2 |
12.3 |
14.5 |
| Neutropenia |
6.1 |
5.5 |
5.7 |
| Other blood disorders |
2.2 |
2.0 |
2.4 |
| Infection |
24.6 |
33.1 |
35.8 |
| History of hospitalization for any reason, % |
50.6 |
49.3 |
49.7 |
| History of CINC-related hospitalization, % |
6.6 |
9.1 |
10.4 |
| History of chemotherapy, % |
9.0 |
6.4 |
6.9 |
| History of radiation therapy, % |
6.5 |
4.3 |
4.0 |
| Pre-Chemotherapy Expenditures ($), Mean ± SD |
34,736 (43,618) |
33,913 (42,458) |
34,480 (43,828) |
| History of conditions/events in prior cycles of same chemotherapy course, % | |||
| Anemia |
18.5 |
18.5 |
19.6 |
| Neutropenia |
38.0 |
45.4 |
44.9 |
| Other blood disorders |
1.5 |
1.5 |
2.2 |
| Infection |
31.9 |
34.2 |
34.3 |
|
Cancer |
|
|
|
| Type, % |
|
|
|
| Female breast |
48.2 |
49.6 |
49.6 |
| Non-Hodgkin’s Lymphoma |
9.9 |
12.8 |
23.3 |
| Trachea, bronchus, lung |
7.5 |
9.5 |
8.1 |
| Prostate |
0.6 |
0.5 |
0.1 |
| Colon/Rectum |
15.9 |
9.8 |
4.6 |
| Other |
17.9 |
17.9 |
14.2 |
| Presence of metastases, % | |||
| Bone |
2.5 |
1.5 |
1.8 |
| Other Site |
35.1 |
30.3 |
29.6 |
|
Chemotherapy | |||
| Cycle number/min. length of prior cycles in same chemotherapy course, % | |||
| 1 |
12.6 |
13.1 |
16.3 |
| 2/12-19 |
5.9 |
4.3 |
4.8 |
| 2/20-26 |
8.3 |
10.8 |
12.1 |
| 2/27+ |
2.1 |
3.0 |
2.7 |
| > = 3/12-19 |
41.5 |
31.8 |
21.1 |
| > = 3/20-26 |
27.8 |
35.3 |
40.5 |
| > = 3/27+ |
1.7 |
1.8 |
2.5 |
| Number of Myelosuppressive Drugs, % | |||
| 1 |
24.3 |
20.0 |
14.5 |
| 2 |
48.0 |
48.2 |
51.3 |
| 3 |
20.6 |
25.4 |
31.3 |
| > = 4 |
7.1 |
6.4 |
3.0 |
| Receipt of Antimicrobial Prophylaxis, % |
6.7 |
7.5 |
7.5 |
| Year of Chemotherapy, % | |||
| 2001-2003 |
19.2 |
19.0 |
26.9 |
| 2004-2006 |
39.2 |
34.2 |
34.2 |
| 2007-2010 | 41.7 | 46.8 | 38.9 |