Table 2.
Thromboelastography and platelet reactivity indices.
| Median (interquartile range) | T2DM (n = 14) | Non T2DM (n = 14) | P value |
|---|---|---|---|
| Thrombus kinetics: | |||
| R time, min | 7.3 (6.6 to 8.5) | 6.6 (4.6 to 7.1) | 0.021 |
| Maximum amplitude, MA, mm | 67.7 (62.0 to 70.1) | 67.4 (63.8 to 74.1) | 0.573 |
| K time, min | 1.8 (1.7to 2.2) | 1.6 (1.2 to 2.3) | 0.476 |
| α-angle | 64.5 (54.5 to 73.1) | 68.6 (58.0 to 66.8) | 0.306 |
| Clot index | − 0.2 (− 1.7 to 0.7) | 1.0 (− 0.9 to 3.3) | 0.044 |
| Rate of thrombus retraction (L) mm/min | 27.8 (11.7 to 70.7) | 78.8 (68.5 to 109.6) | 0.002 |
| Platelet Reactivity | |||
| ARU | 419 (398–422) | 403 (390–404) | 0.623 |
| PRUz | 259 (222–311) | 205 (189–232) | 0.028 |
| Percentage inhibition, % | 20 (9–32) | 32 (22–34) | 0.083 |
| P selectin, μg/ml | 74.8 (59.3 – 77.0) | 53.1 (39.7 – 68.9) | 0.062 |
| CD40 ligand, μg/ml | 2934 (2046–3520) | 3512 (1674–4220) | 0.711 |
R time: Time to form a stable thrombus (min).
Maximum amplitude is the maximum strength of the formed thrombus (mm).
K time: time taken for blood to achieve 20 mm amplitude of thrombus (min).
α angle: Angle between R and the first 20 mm of amplitude tracing.
Both K value and α angle represent the speed of thrombus formation.
Clot index is a dimensionless value, representing overall thrombus strength and is derived from the formula: 0.6516R - 0.3772 K + 0.1224MA + 0.0759α – 7.7922.
Rate of thrombus retraction (L parameter) represents early phase of autolysis and is measured from the rate of decline in thrombus strength after it has reached the peak value, MA.
ARU: arachidonic acid reactive units.
PRUz: P2Y12 reactive units after stimulation with adenosine diphosphate.
Percentage inhibition: 100X (PRUz-PRUb/PRUb).