FIG 1.

Old Cidea^−/− mice exhibit dry hair and hair loss phenotype. (A to D) Phenotype of 10-month-old wild-type mice (+/+) and Cidea^−/− (−/−) mice. Cidea^−/− mice had lighter color and drier hair than wild-type mice. Hair loss (red arrow), dry eyes (blue arrow), and scratch marks (green arrow) were observed in Cidea^−/− mice. (E) Mouse skin appearance at day 0 (pink, telogen), day 6 (gray, early anagen), and day 10 (black, late anagen) after induced anagen. Hairs of 7-week-old telogen mice were unplugged to induce the next anagen. Note that there is no obvious skin color difference at days 6 and 10.