FIG 6.

Defective water repulsion and thermoregulation in Cidea^−/− mice. (A) Images of animals immediately after (left, 0 min) or 25 min after (right) a 2-min immersion in 30°C water. (B and D) Impaired water repulsion in Cidea^−/− mice (−/−). After water immersion, body weight was measured every 5 min for 40 min. Male (B) and female (D) Cidea^−/− mice (−/−) absorb twice as much water as wild-type mice (+/+) after water immersion. Bars represent means ± SEM. For male mice, n = 7 for each genotype; for female mice, n = 4 for each genotype. **, P < 0.01; ***, P < 0.001. (C and E) Defective thermoregulation of Cidea^−/− mice (−/−) after water immersion. After water immersion, rectal temperature was measured every 5 min for 45 min. The data shown at −5 min represent the body temperature just before water immersion. n = 4 for each genotype of both male and female mice. Bars represent means ± SEM. *, P < 0.05; **, P < 0.01; ***, P < 0.001.