(a) Immunohistochemical staining for renal hyaluronan expression in EG-treated rat kidneys (n¼6/group) obtained on days 7, 14, and 21 following EG treatment. (b) The average number of hyaluronan-positive stained cells per high power field. Data represent means±s.d. *P<0.05 and ***P<0.001 versus untreated control; ###P<0.001 versus EG; and !P<0.05 versus EGþP4, two-way analysis of variance followed by a post hoc analysis. C, untreated control (distilled water); EG, EG-treated group (0.8% EG/1% ammonium chloride (AC; NH4Cl) in drinking water); and EG+P4 and EG+P20, two PGG-treated groups (0.8% EG/1% ACþ4 or 20 mg/kg of PGG in 2% methylcellulose).