FIG 4.

Histological and pathological analysis of PGC-1 mutant mice at birth. (A) Wright-Giemsa staining of peripheral blood smears of wild-type (WT) or PGC-1 compound mutant (Pgc-1^c) newborns at p0. Arrows indicate erythroblasts (primitive nucleated erythrocytes). (B) Hematoxylin and eosin (H&E)-stained liver or spleen sections from WT and Pgc-1^c mice revealed necrotic cell death and cell loss in Pgc-1^c livers and spleens. Additionally, Pgc-1^c livers and spleens accumulated abnormal numbers of adipocytes, displaying abundant accumulation of large lipid droplets.