FIG 5.

Renal tubular cell-specific Gata2 deletion leads to high urine volume and low urine osmolality. (A and B) Volume and osmolality of 24-hour urine in Gata2-CKO (n = 10) and littermate control (Gata2^flox/flox; n = 6) mice. Statistical significance of the differences between Gata2-CKO and the control littermates is indicated (***, P < 0.001; Student's unpaired t test). (C) Twenty-four-hour solution intake of control and Gata2-CKO mice (***, P < 0.001; Student's unpaired t test). (D) No obvious histological abnormality in glomeruli (a and b) and CD (c and d) in the Gata2-CKO in comparison with the Gata2^flox/GFP littermate control mice. Scale bars, 50 μm.