FIG 6.

Gene expression profile in CD cells. (A) Heat map generated from DNA microarray data of water reabsorption-related genes changed in CD cells of Gata2 CKO mice. Heat map colors indicate normalized expression level (log₂). Genes are categorized into three groups by their function using Ingenuity pathway analysis (IPA) software and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database (http://www.genome.jp/kegg/pathway.html). (B) mRNA expression of Aqp3, Aqp4, Gata3, Creb, and Avpr2 in the CD cells of Gata2^flox/flox and Gata2-CKO mice examined by qRT-PCR analysis. The statistical significance of the difference between the Gata2^flox/flox and Gata2 CKO mice is indicated (*, P < 0.05; Student's unpaired t test, N.S; not significant).