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. 2014 Jun;34(11):2062–2074. doi: 10.1128/MCB.00197-14

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Copyright © 2014 Knobel et al.

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FIG 3 — Normal DNA damage-signaling and checkpoint responses in USP28-depleted cells. Western blotting of 2 or 10 Gy IR-treated (A) or camptothecin-treated (CPT at 1 μM for 1 h) (B) U2OS cells at the indicated time points. Cells were transfected with siRNAs for luciferase (siLuc) or USP28. Western blotting results for MEFs treated with 5 Gy IR (C) or 10 J/m² UV-C (D) at the indicated time points are shown. (E) The G₁ checkpoint was intact in RPE-1 cells depleted of siRNA for USP28 or 53BP1 but not ATM. (F) G₂/M checkpoint responses were normal in MEFs lacking USP28.