FIG 7.

Cross-sectional assessment of the levels of T cell immune activation and proliferation in wild sabaeus monkeys from the Gambia. Immune activation was measured as the fraction of CD4⁺ (a) and CD8⁺ T cells (b) expressing HLA-DR. Cell proliferation was measured as the fraction of CD4⁺ and CD8⁺ T cells expressing Ki-67. Infant AGMs are illustrated as open circles and squares; juvenile AGMs are illustrated as gray circles and squares; adult AGMs are shown as black circles and squares. Samples collected from female AGMs are illustrated as circles (○); samples collected from male AGMs are shown as squares (□); the samples from acutely infected adult females (defined as having high viral loads and negative serologies) are illustrated as open circles with enhanced margins; the sample collected from a juvenile male AGM with high viral loads but seropositive (probably postacutely infected) is shown as a half-empty square. P values were calculated by the Mann-Whitney U test. The values on the y axes depict the fraction of activated or proliferating CD4⁺ or CD8⁺ T cells.