FIG 5.

Expression patterns of esIFN-κ, esIFN-ω, and IFN-induced genes after lyssavirus infection. An E. serotinus brain cell line was infected with EBLV-1, EBLV-2, or RABV (MOI of 0.1) for 24 h, and the expression of esIFN-κ and esIFN-ω (A) and IFN-induced genes ISG56, Mx1, and IFIT3 (B) was measured by qRT-PCR. Note the downregulation of esIFN-κ by 50% in the virus-infected cells (A) and the weakly increased expression of ISG56 after EBLV-2 infection, whereas the expression level of all of the other IFN-induced genes was not changed (B).