TABLE 1.

Identification of top downregulated genes based on hierarchical clustering of all differentially expressed genes in NEO, CR, and CT

Gene	Fold change
	1 min			60 min
	NEO-CR	NEO-CT	CT-CR	NEO-CR	NEO-CT	CT-CR
MAGEA6	−11.4	−39.2	−0.21	0	0	−0.21
MAGEA3	−8.31	−19.59	−0.26	0	0	−0.12
DDC	−6.77	−1.26	−2.05	0	0	−1.09
MAGEC1	−6.12	−5.11	0	0	0	0
ZNF32	−5.62	−1.52	−1.71	−2.57	−0.3	−3.04
VAMP8	−4.1	−7.2	1.04	0	0	1.73
HSPA1A	−0.54	−1.71	0.65	−0.37	−1.35	0.67
BHLHB2	0.74	−2.74	4.58	0.69	−1.95	2.83
HSPA1B	−0.59	−2.1	0.68	−0.59	−1.88	0.98
LYZ	−0.59	−3.32	2.05	0.5	−2.14	1.96
GPRC5B	−0.92	−4.04	1.64	0.35	0	1.53
LAMA3	−1.83	−2.86	0.82	−0.21	−0.33	0.87
MYB	−1.02	−1.9	0.96	−0.97	−1.64	0.98
E2F2	−1.17	2.02	−3.49	−0.89	1	−1.1
HEY1	−0.94	1.92	−3.22	−0.9	1.6	−1.86
DDC	−4.62	−0.83	−2.54	0	0.4	−2.13
ID4	−1.98	0.75	−2.52	−1.1	0.8	−1.56
FASN	−0.66	1.38	−2.39	−1.15	1.37	−2.49
HLA-DQA1	0.19	1.81	−2.37	0.5	2.14	−2.07
LTK	−5.3	−2.31	−0.87	−3.69	−3.78	−0.54
TPM2	−3.61	−1.62	−1.05	−3.25	−1.25	−0.5
AGTRL2	0.29	−0.19	0.3	−2.64	−0.89	−2.04
ANXA2	−2.94	−1.25	−0.38	−2.49	−0.86	−0.11
G6PD	−1.22	−0.6	−0.92	−2.46	−0.81	−1.46
TXNIP	−0.95	−1.54	0.67	−1.01	−2.75	1.19
C20orf97	1.21	−1.55	3.01	0.92	−2.72	3.06
GADD45B	0.9	−1.74	1.91	−0.72	−2.63	1.86
PPP1R15A	0.93	−4.14	4.48	0.96	−2.63	2.77
ZNF198	−0.55	−1.59	1.02	−1.1	−2.53	1.63
PSCD3	−1.99	−2.26	0.89	−0.74	−2.52	0.53
HLA-DQA1	0.83	2.31	−1.68	0.6	3.67	−2.49
GNMT	0.75	1.04	−1.07	−1.79	1.18	−2.48
CCNE2	0.25	1.47	−0.89	−0.98	1.35	−2.47
GPRK6	−1.42	1.15	−1.74	−0.6	1.37	−2.32
DLAT	−1.49	−0.94	−1.54	−2.07	1.01	−2.31
MAP2K6	0.88	3.13	−1.48	−1.7	1.13	−2.3