FIG 4.

Number of host genes and pathway analysis of genes differentially regulated by poxvirus infection. (A) Shown are the numbers of cellular genes that exhibited expression changes in our microarray analyses larger than 2-fold or less than 2-fold at 6 h after infection with each virus. (B) Intersections of gene upregulation (fold change [fc] of >2) or downregulation (fold change of <2) in macrophages infected with the indicated viruses are shown in the Venn diagrams. (C) Ingenuity Pathway analysis showing selected canonical pathways significantly modulated in macrophages infected with the indicated poxviruses compared to naive macrophage controls (P < 0.05). The dashed line indicates the threshold set at 1.5 log (P value). ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; GM-CSF, granulocyte-macrophage colony-stimulating factor.