Summary of mutations and substitutions detected in each of 11 genes (VP1 to VP4, VP6, VP7, and NSP1 to NSP5/6 [A to K, respectively]) during serial passages in mice and/or in cell cultures. “nt” and “aa” indicate nucleotides and amino acids, respectively. Blue and yellow-green backgrounds indicate nonsynonymous substitutions and untranslated regions, respectively. Yellow, gray, and pink backgrounds indicate mutations only detected in mouse-passaged virus, in cell culture-passaged virus, or both, respectively. ND, no sequencing data.