TABLE 3.
Amino acid residues at the cleavage site of the HA protein of avian H5N2 virusesa
| Isolation date (mo/yr) | Strainb | Amino acid residue at: |
||||||
|---|---|---|---|---|---|---|---|---|
| HA1 position |
HA2 position +1 | |||||||
| −6 | −5 | −4 | −3 | −2 | −1 | |||
| 1994 | Ck/Hidalgo/28159-232/94 | P | Q | R | E | T | R | G |
| 2005 | Ck/Ibaraki/1/05 | P | Q | R | E | T | R | G |
| 12/2003 | Ck/TW/1209/03 | P | Q | R | E | K | R | G |
| 10/2008 | Ck/TW/A703-1/08 | P | Q | R | K | K | R | G |
| 1/2012 | Ck/TW/0101/12 | P | Q | R | K | K | R | G |
| 2/2012 | Ck/TW/A1997/12 | P | Q | R | R | K | R | G |
| 12/2012 | Ck/TW/683/12-like (n = 3) | P | Q | R | E | K | R | G |
| Ck/TW/2593/12 | P | Q | R | E | K | R | G | |
| 1/2013 | Ck/TW/1680/13-like (n = 5) | P | Q | R | K | K | R | G |
| 3/2013 | Ck/TW/2948/13 | P | Q | R | E | K | R | G |
| Ck/TW/7350/13 | P | Q | R | K | K | R | G | |
| Ck/TW/8994/13-like (n = 3) | P | Q | R | K | K | R | G | |
| Ck/TW/8996/13 | P | Q | R | E | K | R | G | |
| 5/2013 | Ck/TW/4443/13 | P | Q | R | E | K | R | G |
a
The glycosylation site at +11 (H3 numbering) is conserved in all viruses in this table.
b
Three viruses (Ck/TW/1680/13, Ck/TW/8994/13, and Ck/TW/8996/13) were selected for determination of pathogenicity in day-old chickens using the intracerebral pathogenicity index (ICPI).