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. 2014 May;88(10):5677–5686. doi: 10.1128/JVI.00139-14

TABLE 3.

Amino acid residues at the cleavage site of the HA protein of avian H5N2 virusesa

Isolation date (mo/yr) Strainb Amino acid residue at:
HA1 position
HA2 position +1
−6 −5 −4 −3 −2 −1
1994 Ck/Hidalgo/28159-232/94 P Q R E T R G
2005 Ck/Ibaraki/1/05 P Q R E T R G
12/2003 Ck/TW/1209/03 P Q R E K R G
10/2008 Ck/TW/A703-1/08 P Q R K K R G
1/2012 Ck/TW/0101/12 P Q R K K R G
2/2012 Ck/TW/A1997/12 P Q R R K R G
12/2012 Ck/TW/683/12-like (n = 3) P Q R E K R G
Ck/TW/2593/12 P Q R E K R G
1/2013 Ck/TW/1680/13-like (n = 5) P Q R K K R G
3/2013 Ck/TW/2948/13 P Q R E K R G
Ck/TW/7350/13 P Q R K K R G
Ck/TW/8994/13-like (n = 3) P Q R K K R G
Ck/TW/8996/13 P Q R E K R G
5/2013 Ck/TW/4443/13 P Q R E K R G
a

The glycosylation site at +11 (H3 numbering) is conserved in all viruses in this table.

b

Three viruses (Ck/TW/1680/13, Ck/TW/8994/13, and Ck/TW/8996/13) were selected for determination of pathogenicity in day-old chickens using the intracerebral pathogenicity index (ICPI).