FIG 3.

Kaplan-Meier survival curves of rat offspring after i.p. injections with K. kingae. PN 21 or PN 7 rats were injected with different doses of K. kingae strains or PBS. The animals were monitored for mortality and clinical signs of illness twice a day for 14 days. After the initial 72 h, no additional mortality was detected. These data were combined from three separate experiments. (A) The survival curve of 21-day-old rats injected with 1.3 × 10⁸ bacterial cells/animal of either PYKK081 or KKNB100 demonstrated no significant difference in mortality (log rank test, P > 0.05). (B) The survival curves of 7-day-old rats injected with 4.5 × 10⁷, 2.0 × 10⁷, and 1.2 × 10⁷ bacterial cells/animal all demonstrated significant difference in mortality when comparing PYKK081 and KKNB100. Additionally, survival curves were significantly dependent upon the concentration of injected PYKK081 (log rank test for trend, P < 0.0001).